Neem has anti-spirochaetal properties so that it works as both as a preventative measure and in the treatment of primary, secondary and tertiary stages of syphilis (Siddiqui and Mitra, 1945); (Bhandari and Mukerjii, 1959); (Puri, 1993).
Neem creams used as a vaginal lubricant or birth control may be effective against the syphilis spirochete and may prevent contraction of the disease. As with gonorrhea, creams containing at least 25 percent neem oil were used.
Drinking neem tea made three times per day or four capsules a day for two weeks is recommended as treatment.