Inhibition of prostaglandin synthetase by limonoids (and/or polysaccharides) reduces perceived pain.
Both as topical applications and as oral medicines, Neem provides a low cost pain reliever and fever-reducing remedy. Neem leaf and bark extracts have been shown to be a more potent inhibitor of prostaglandin synthetase than acetylsalicylic acid (aspirin) and pethidine hydrochloride. (Okpako, 1977); (Pillai, 1978b); (Tandan, et al, 1990).
In some cases neem was effective at reducing pain for a significantly longer period than standard agents. Neem also reduces the activity of the central nervous system, which also reduces perceived pain (Debelmas, 1976).
According to a study led by N. Khanna, neem produces an analgesic effect upon the central and peripheral neural pathways. He also feels that both opioid and non-opioid receptors can be affected by neem.(Khanna et al, 1995)
Inhibitor of prostaglandin synthetase Neem leaf and bark extracts have been shown to be a more potent inhibitor of prostaglandin synthetase than acetylsalicylic acid (aspirin) and pethidine hydrochloride. In some cases neem was effective at reducing pain for a significantly longer period than standard agents. Neem also reduces the activity of the central nervous system, which also reduces perceived pain. According to a study led by N. Khanna, neem produces an analgesic effect upon the central and peripheral neural pathways. He also feels that both opioid and non-opioid receptors can be affected by neem.
